The Iranian form of psychometric properties of the Multidimensional Psychological Flexibility Inventory

The Multidimensional Psychological Flexibility Inventory (MPFI) is a new 60-item self-report scale developed to assess the specific components of psychological flexibility and inflexibility proposed in the Hexaflex model of Acceptance and Commitment Therapy (ACT). The present study sought to examine the psychometric properties of the Persian version of the MPFI-60 in a community sample of 307 Iranian adults. The original study supported a 12-factor second-order structure consisting of 6 dimensions for psychological flexibility and 6 dimensions for psychological inflexibility. The Persian MPFI-60 demonstrated acceptable semantic and test content, internal structure, correlations with other variables, and internal consistency. It also evidenced in relation to anxiety, stress, depression, and self-compassion. Overall, the results indicate that the Persian MPFI-60 is a psychometrically sound measure in the Iranian context that enables researchers and clinicians to comprehensively assess the components of psychological flexibility and inflexibility within the Hexaflex model. (AU)

The impact of health literacy of Iranian users on the accuracy of information on COVID-19 in virtual social networks

The aim of the present study is to investigate the impact of health literacy of Iranian users on the accuracy of information on COVID-19 in virtual social networks. This is applied descriptive survey. The population includes all Iranian users of virtual networks (Telegram, WhatsApp, Twitter, Instagram and etc.). In this study, 121 questionnaires were confirmed and studied. For descriptive statistics, SPSS (ver. 32) and for testing hypothesis, Lisrel have been used. The research findings show that according to Iranian users, Internet is the main source for obtaining information on COVID-19. Moreover, the most popular virtual network is WhatsApp. The aim of using virtual social networks is to access to news and information. The results of structural equations show that there is positive meaningful relation between the rate of health literacy and the accuracy of information on COVID-19 (p > 0.000, ß = 0.561). In addition, the health literacy can explain 40 percent variance of the accuracy of information on COVID-19 in virtual social networks. Moreover, the results show that there is meaningful difference between the educational level of Iranian users and the health literacy and accuracy of information on COVID-19 in virtual social networks. Concerning the results of this study and meaningful relation between the health literacy level and attention to accuracy of the information on COVID-19 in Iranian users, the authorities of health system are recommended to consider special planning and policies to increase the health literacy level of users in social networks. In this way, users will be able to verify the accuracy of information on COVID-19 by increasing their health literacy level and therefore, there would be less losses due to unawareness of health literacy and its adverse effect(AU)

El objetivo del presente estudio es investigar el impacto de la alfabetización en salud relacionada con la COVID-19 en los usuarios iraníes de las redes sociales virtuales. Se aplicó una encuesta descriptiva, que incluyó a todos los usuarios iraníes de redes sociales virtuales (Telegram, WhatsApp, Twitter, Instagram, etc.). En el estudio se confirmaron y estudiaron 121 cuestionarios. Para estadística descriptiva se utilizó SPSS (versión 32) y Lisrel, para probar la hipótesis. La investigación indicó que, según los usuarios iraníes, Internet es la principal fuente de información sobre COVID-19; además, la red virtual más popular es WhatsApp. El objetivo del uso de las redes sociales virtuales es acceder a noticias e información. Los resultados de las ecuaciones estructurales muestran que existe una relación significativa y positiva entre la tasa de alfabetización en salud y la precisión de la información sobre COVID-19 (p > 0,000; ß = 0,561). Asimismo, la alfabetización en salud puede explicar una variación del 40 por ciento en la precisión de la información sobre COVID-19 en las redes sociales virtuales. También que existe una diferencia significativa entre el nivel educativo de los usuarios iraníes, la alfabetización en salud y la precisión de la información sobre COVID-19 en las redes sociales virtuales. Teniendo en cuenta los resultados de este estudio, se recomienda a las autoridades del sistema de salud que consideren una planificación y políticas especiales para aumentar el nivel de alfabetización en salud de los usuarios en redes sociales. De esta manera, estos últimos podrán verificar la información sobre COVID-19 y, por lo tanto, serían menores las pérdidas por desconocimiento(AU)

Investigation of anti-Alzheimer's activity of aqueous extract of areca nuts (Areca catechu L): in vitro and in vivo studies / Investigación de la actividad anti-Alzheimer del extracto acuoso de nueces de areca (Areca catechu L): estudios in vitro e in vivo

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Sever cognitive and memory impairments, huge increase in the prevalence of the disease, and lacking definite cure have absorbed worldwide efforts to develop therapeutic approaches. Since many drugs have failed in the clinical trials due to multifactorial nature of AD, symptomatic treatments are still in the center attention and now, nootropic medicinal plants have been found as versatile ameliorators to reverse memory disorders. In this work, anti-Alzheimer's activity of aqueous extract of areca nuts (Areca catechu L.) was investigated via in vitro and in vivo studies. It depicted good amyloid ß (Aß) aggregation inhibitory activity, 82% at 100 µg/mL. In addition, it inhibited beta-secretase 1 (BACE1) with IC50 value of 19.03 µg/mL. Evaluation of neuroprotectivity of the aqueous extract of the plant against H2O2-induced cell death in PC12 neurons revealed 84.5% protection at 1 µg/mL. It should be noted that according to our results obtained from Morris Water Maze (MWM) test, the extract reversed scopolamine-induced memory deficit in rats at concentrations of 1.5 and 3 mg/kg.

La enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo relacionado con la edad. Los severos deterioros cognitivos y de la memoria, el enorme aumento de la prevalencia de la enfermedad y la falta de una cura definitiva han absorbido los esfuerzos mundiales para desarrollar enfoques terapéuticos. Dado que muchos fármacos han fallado en los ensayos clínicos debido a la naturaleza multifactorial de la EA, los tratamientos sintomáticos siguen siendo el centro de atención y ahora, las plantas medicinales nootrópicas se han encontrado como mejoradores versátiles para revertir los trastornos de la memoria. En este trabajo, se investigó la actividad anti-Alzheimer del extracto acuoso de nueces de areca (Areca catechu L.) mediante estudios in vitro e in vivo. Representaba una buena actividad inhibidora de la agregación de amiloide ß (Aß), 82% a 100 µg/mL. Además, inhibió la beta-secretasa 1 (BACE1) con un valor de CI50 de 19,03 µg/mL. La evaluación de la neuroprotección del extracto acuoso de la planta contra la muerte celular inducida por H2O2 en neuronas PC12 reveló una protección del 84,5% a 1 µg/mL. Cabe señalar que, de acuerdo con nuestros resultados obtenidos de la prueba Morris Water Maze (MWM), el extracto revirtió el déficit de memoria inducido por escopolamina en ratas a concentraciones de 1,5 y 3 mg/kg.

Evaluating the Occupational Health and safety Engineering Internship Course from the Perspective of Trainees: At Developing and Validating A New Tool

@#Introduction: The internship course is a very important part of each university course. The present study aimed at designing and validating a standard instrument for evaluating the internship course in the field of Occupational Health and Safety Engineering (OHSE) from the perspective of trainees. Methods: The dimensions and items of the tool were developed using the panel of experts, syllabus provided by the Iranian Ministry of Health and Medical Education, and literature reviews. Validity of the tool was assessed using face validity, Content Validity Ratio (CVR), Content Validity Index (CVI), and Impact Score (IS). Reliability was evaluated by test–retest reliability analyses and internal consistency (Cronbach’s alpha coefficient). Finally, the internship courses were evaluated during three subsequent years (2016-2018) among 45 students of Shahroud University of Medical Sciences (SHMU) in Iran. Results: The final version of the tool contained five dimensions and 20 items. The CVI and CVR were 0.81 and 0.74, respectively. The ISs of all 20 items were above the minimum acceptable value (1.5). The Cronbach’s alpha coefficient was 0.79 and test-retest Pearson’s correlation coefficient was significant at 0.891 (p<0.001). The overall mean score of evaluation was estimated to be 3.81, which was acceptable. However, poor mean scores were obtained in “access to equipment and laboratory instruments” and “familiarity with job opportunities and internship” dimensions. Conclusions: The results of this study led to a valid tool for evaluating the OHSE internship course. This standard tool can be used to evaluate the perspective of OHSE trainees about the training period and use the results to correct the weaknesses and reinforce the strengths of the training programs.

CG/CA genotypes represent novel markers in the NPHS2 gene region associated with nephrotic syndrome

Nephrotic syndrome (NS) is considered as a primary disease of the kidney that represents a heterogeneous group of glomerular disorders occurring mainly in children. It is generally divided into steroid-sensitive and steroid-resistant forms, depending upon the patient’s response to steroid therapy. Among the genes involved, the NPHS2 gene has been reported as the causative gene in steroid resistant form of nephrotic syndrome. In the present study, heterozygosity rate, allelic frequency and linkage of rs2274625 and rs3829795 markers were investigated in the NPHS2 gene region. To determine the SNP alleles, tetra-primer ARMS PCR was used. After genotyping rs2274625 and rs3829795 polymorphic markers in 120 unrelated individuals and nine trios families, the data were analysed using various computer programs such as UCSC Genome Browser, dbSNP and SNPper. Based on the statistical analysis of the results, for rs2274625 marker, allele frequency for C and T alleles was 97% and 3%, respectively. For rs3829795 marker allele frequency for G and A alleles was 55% and 45%, respectively. The values of heterozygosity index for the examined markers were 5% for rs2274625 and 45/8% for rs3829795. Consequently, two informative haplotypes, CG/CA, were identified in the NPHS2 gene region through combination of these two markers. These haplotypes can serve as appropriate tools for the identification of heterozygous carriers and linkage analysis of nephrotic syndrome disease in the Iranian families with an affected child.

Clinical features and tubulin folding cofactor E gene analysis in Iranian patients with Sanjad-Sakati syndrome / Características clínicas e análise genética e de cofatores de dobramento da tubulinaem pacientes iranianos com síndrome de Sanjad-Sakati

Abstract Objective Permanent hypoparathyroidism can be presented as part of genetic disorders such as Sanjad-Sakati syndrome (also known as hypoparathyroidism—intellectual disability-dysmorphism), which is a rare autosomal recessive disorder. Our aim was to confirm the diagnosis of a group of patients with dysmorphism, poor growth, and hypoparathyroidism clinically labeled as Sanjad-Sakati syndrome and to identify for the first time the genetic variations on Iranian patients with the same ethnic origin. Methods In this study, 29 cases from 23 unrelated Arab kindreds with permanent hypoparathyroidism and dysmorphism indicating Sanjad-Sakati syndrome were enrolled for 10 years in the southwest of Iran. The mutational analysis by direct sequencing of the tubulin folding cofactor E gene was performed for the patients and their families, as well as their fetuses using genomic DNA. Results Twenty-eight out of 29 cases had parental consanguinity. Twenty-seven cases presented with hypocalcemia seizure and two were referred because of poor weight gain and were found to have asymptomatic hypocalcemia. The dysmorphic features, hypocalcemia in the setting of low to normal parathyroid hormone levels and high phosphorus led to the diagnosis of these cases. Sequencing analysis of the tubulin folding cofactor E gene revealed a homozygous 12-bp deletion (c.155-166del) for all patients. Following that, prenatal diagnosis was performed for eight families, and two fetuses with a homozygous 12-bp deletion were identified. Conclusion These results make it much easier and faster to diagnose this syndrome from other similar dysmorphisms and also help to detect carriers, as well as prenatal diagnosis of Sanjad-Sakati syndrome in high-risk families in this population.

Resumo Objetivo O hipoparatireoidismo permanente pode estar presente como parte das doenças genéticas como na síndrome de Sanjad-Sakati (também chamada de síndrome de hipoparatireoidismo, retardo e dismorfismo), que é um distúrbio autossômico recessivo raro. Nosso objetivo foi confirmar o diagnóstico de um grupo de pacientes com dismorfismo, crescimento deficiente e hipoparatireoidismo clinicamente identificado como síndrome de Sanjad-Sakati e identificar as variações genéticas, pela primeira vez, em pacientes iranianos com a mesma origem étnica. Métodos Neste estudo, foram inscritos 29 casos de 23 famílias árabes sem parentesco com hipoparatireoidismo e dismorfismo indicando síndrome de Sanjad-Sakati, durante 10 anos no sudoeste do Irã. Foi feita a análise mutacional por sequenciamento direto do gene do cofator E de dobramento da tubulina dos pacientes e de suas famílias e também de seus fetos com o DNA genômico. Resultados Apresentaram consanguinidade parental 28 dos 29 casos. Desses, 27 casos apresentaram convulsão por hipocalcemia e dois foram encaminhados devido ao baixo ganho de peso, considerando diagnóstico de hipocalcemia assintomática. As características dismórficas, hipocalcemia na configuração de níveis de hormônio da paratireoide baixos a normais e alto nível de fósforo levaram ao diagnóstico dos casos. A análise de sequenciamento do gene do cofator E de dobramento da tubulina revelou deleção homozigótica de 12 pares de base (pb) (c.155-166del) em todos os pacientes. Após isso, foi feito o diagnóstico pré-natal em oito famílias e dois fetos foram identificados com deleção homozigótica de 12 pb. Conclusão Esses resultados tornam o diagnóstico dessa síndrome muito mais fácil e rápido do que outros dismorfismos semelhantes e também ajudam a detectar portadores, bem como o diagnóstico pré-natal da síndrome de Sanjad-Sakati em famílias de alto risco nessa população.

Accuracy of Demirjian’s Method to Estimate Chronological Age in 5‒17-Year-Old Iranian Population

Introduction:To detect physiological maturity of a child, use of dental and skeletal development can be helpful. The Demirjian’s Method is one of the commonly used methods to estimate dental age. The aim of the present study was to evaluate the validity of Demirjian method in Iranian population with different races.Materials and Methods:The present cross-sectional study was performed on a randomly selected sample of panoramic radiographs of 3073 patients aged 5‒17 years. The chronological age (CA) was calculated by subtracting the date of birth from the date on which the radiographs were taken. Estimated age (EA) was performed by Demirjian method using seven left mandibular teeth. Paired t-test was used to compare differences between chronological and estimated age.Results:The mean of CA was 11.14±2.61 years whereas the mean EA was 11.35±2.62; Original Research Article therefore, EA was calculated 2.5 months more than CA. According to paired t-test the difference between CA & EA was significant (P≤ 0.001). Pearson’s correlation coefficient showed a strong linear correlation between CA and EA in total (r=0.891, P≤0.001), in girls (r=0.895, P≤ 0.001) and in boys (r=0.876, P≤ 0.001). The new regression line equation based on Iranian standards would be CA=1.08±0.89EA in total, CA=1.09±0.89EA in girls and CA=1.12+0.88EA in boys. Conclusion:Using Demirjian’sMethod overestimated dental age in the Iranian population. A new regression line equation based on Iranian standards was obtained according to the results of the present study

Management of acute cough by Zataria multiflora Boiss as an alternative treatment / 中西医结合学报

Cough, as a defensive reflux mechanism, removes foreign objects and secretions from bronchi and bronchioles of airways. Zataria multiflora is a popular plant for treatment of cough in Iranian traditional medicine. The aim of this review was to evaluate the potency of Z. multiflora as an alternative treatment in management of acute cough and its possible mechanisms of action. Here the authors compiled information about Z. multiflora in the treatment of cough from all accessible resources and books. The results of this investigation showed that there were five clinical studies that evaluated the efficacy of Z. multiflora essential oil or extract alone (n = 1), in combination with Althaea officinalis (n = 2) or Foeniculum vulgare essential oil (n = 1), in the form of syrup (n = 3), oral drop (n = 1) and soft capsule (n = 1), for the treatment of acute cough in comparison with placebo or synthetic drugs (bromhexine, dextromethorphan and clobutinol). All clinical studies confirmed the efficacy of Z. multiflora in the amelioration of acute cough in pediatric (n = 1) and adult patients (n = 4) without any adverse effects. Different mechanisms, such as anti-inflammatory, analgesic, antimicrobial, relaxant and immune-enhancement, may be responsible for the efficacy of Z. multiflora in cough relief. Other clinical trials can be performed with Z. multiflora in combination with ivy leaf extract or primrose root extract on patients with cough.

Traditional and modern aspects of hemorrhoid treatment in Iran: a review / 中西医结合学报

Hemorrhoidal disease is a prevalent anorectal condition which is generally not managed well with current pharmacologic interventions. However, in Iranian traditional medicine (ITM) there are numerous plants with hemorrhoid-healing properties. The present research assembled plants with hemorrhoid-healing properties in ITM; their related pharmacological effects, phytochemical constituents and mechanisms of action in the modern medicine were also gathered. For this purpose, leading ITM textbooks were searched for plants with hemorrhoid-healing effects. Further, in vitro, in vivo and clinical studies on the most cited species were considered using scientific databases. Studying ITM textbooks revealed 37 medicinal plants with hemorrhoid-healing effects. Among the mentioned herbal medicines, six species, including Allium ampeloprasum, Phyllanthus emblica, Aloe vera, Terminalia chebula, Vitis vinifera and Commiphora mukul, had the largest number of related pharmacological effects documented in scientific databases. These herbs from ITM should be considered as important resources for producing novel drugs for hemorrhoid treatment.

Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs

Objective: To assess the ameliorative properties of Iranian Trigonella foenum-graecum L. (T. foenum-graecum) seeds and Punica granatum L. (P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea pigs. Methods: Sixty guinea pigs were divided into six groups (10 guinea pigs per group). Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, respectively. All animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were measured. Results: Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters (blood urea nitrogen and creati-nine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed sig-nificant protective properties with respect to body weight gain and other biochemical parameters studied. Conclusions: The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.

Evaluating the association of VSX1 mutation with keratoconus and the granular corneal dystrophy in an Iranian family / 国际眼科杂志(Guoji Yanke Zazhi)

AIM: To evaluate association between mutations in the visual system homeobox 1 (VSX1) gene and keratoconus (KCN) complicated with granular corneal dystrophy (GCD), direct sequencing was performed in an Iranian family affected by KCN and GCD in four generations.METHODS: An Iranian pedigree with keratoconus spanning four generations along with GCD was identified.Whole blood sample was used for genomic DNA extraction.The molecular analysis by using polymerase chain reaction (PCR) of the entire coding region and intron-exon boundaries of VSX1 gene was preformed to investigate the possible linkage between KCN and GCD.Subsequently, direct sequencing was used for PCR products and mutation analysis was conducted in the patients and controls.RESULTS: Mutation analysis in VSX1 gene did not detect evidence for association between KCN and GCD diseases and VSX1 gene.Our data excluded VSX1 as the disease-causing gene for KCN/GCD in this specific pedigree.CONCLUSION: Despite of no association between KCN patients with GCD and VSX1 gene variations, other probable genes involved in pathogenesis of the KCN and GCD diseases need to be investigated in the patients.

Ameliorative properties of Iranian Trigonella foenum-graecum L. seeds and Punica granatum L. peel extracts in streptozotocin-induced experimental diabetic guinea pigs

Objective To assess the ameliorative properties of Iranian Trigonella foenum-graecum L. (T. foenum-graecum) seeds and Punica granatum L. (P. granatum) peel extracts against streptozotocin-induced diabetes in male guinea pigs. Methods Sixty guinea pigs were divided into six groups (10 guinea pigs per group). Group 1 consisted of normal animals. Groups 2 and 3 were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract alone, respectively. Group 4 was treated with streptozotocin only; whereas Groups 5 and 6 receiving streptozotocin were treated with Iranian T. foenum-graecum seeds and P. granatum peel extract, respectively. All animals were treated for 30 days, and the body weight, blood and liver biochemical parameters were measured. Results Guinea pigs exposed to streptozotocin showed an alteration in body weight gain, fasting glucose level, kidney function parameters (blood urea nitrogen and creatinine) as well as decreased serum and hepatic total protein level. In addition, it increased the cholesterol and triglyceride level, while decreasing the hepatic glucose-6 phosphate dehydrogenase activity, glycogen, glutathione content and hepatic catalase activity. Oral treatment with T. foenum-graecum seeds and P. granatum peel extracts revealed significant protective properties with respect to body weight gain and other biochemical parameters studied. Conclusions The Iranian T. foenum-graecum seeds and P. granatum peel extracts are significantly potent in ameliorating diabetic condition induced by streptozotocin and improving various biochemical parameters in serum and liver of guinea pigs.

Human parvovirus B19 in patients with beta thalassemia major from Tehran, Iran

BACKGROUND: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran. METHODS: This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time polymerase chain reaction assay. RESULTS: The prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analysis of human parvovirus B19 revealed genotype I in these six patients. CONCLUSION: In this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and disease-prevention measures.

Polymorphisms of Promoter Region of TNF-α Gene in Iranian Azeri Turkish Patients with Behçet's Disease

Behçet’s disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. Alterations of the tumor necrosis factor (TNF) expression related to the polymorphic alleles of TNF gene may implicate a pathogenetic role in increased activity of this cytokine in BD. A current study aimed at investigating the possible association between BD and its clinical features in Iranian Azeri Turks with two functional TNF-α gene polymorphisms (at the positions of -238 and -857). A total number of 166 Iranian subjects were enrolled into two different groups; patients with BD (n = 64), and ethnically matched healthy controls (n = 101). The genotype distributions of BD patients and healthy controls were determined. The frequency of TNF-α -857C allele was significantly higher in Behçet’s patients than that of healthy controls (P = 0.001; odds ratio [OR] = 2.616; 95% confidence interval [CI] = 1.129–6.160), whereas the frequency of TNF-α -238A allele was similar in both groups. The sole TNF-α haplotype-857C-1031C, was associated with an increase in the risk of developing BD. The TNF-α -857C allele was considerably associated with BD in this cohort. The findings of this study, collectively, indicate that TNF-α -857C-1031C haplotype located in the promoter region of the gene could exert major influence on the susceptibility to BD.

Estimation of Stature in Iranian Adults Using Knee Height

This study aimed to establish an equation for stature prediction using knee height in the Iranian population. Methods: Anthropometric measurements of 320 (193 women and 127 men) healthy dormitory students of a medical sciences university were taken by a trained dietitian to minimise errors. Linear regression analysis was used to estimate stature with height as the dependent variable and knee height and age as independent variables. A control group (63 women and 67 men) was used for validation of prediction equations. Results: The developed regression equations for height estimation by using knee height in Iranian men and women were 62.913 + (2.077 × Knee height) and 76.362 + (1.76 × Knee height) respectively. There was no significant difference between estimated mean height derived from the present study equation and actual mean height in the control group. Conclusions: New stature prediction equations for both sexes using knee height are presented for the Iranian adult population, which may be different from those for other populations.

Association of VDR FokI and ApaI Genetic Polymorphisms with Parkinson’s Disease Risk in South Western Iranian Population.

Background: Parkinson’s disease comes second comparing to Alzheimer’s disease being responsible for nerve destructing diseases; it is a complex and multifactorial disease. Gene associated studies help to identify the genetic factors that introduce the Single Nucleotide Polymorphisms in different genes as genetic risk factors for non-Mendelian Parkinson’s disease in diverse populations. We intended to study the association of VDR (Vitamin D Receptor) gene polymorphisms with Parkinson’s disease in south western Iranian population. Results: In the present study 150 patients with Parkinson’s disease and 160 Healthy controls from an Iranian population were genotyped for two polymorphic sites. The prevalence of VDR polymorphisms in two restriction fragment length polymorphism sites including FokI and ApaI were analyzed in patients and controls. Our data demonstrated no significant association between VDR FokI polymorphism and PD, whereas the ApaI polymorphism showed a significant association with PD in Iranian patient. Also no association between the age at onset, the male-female ratio and the VDR polymorphism in the PD group was detected. Conclusions: In conclusion these results determined that VDR ApaI (TG and GG) genotype might affect development of PD in our study population. There was no association between FokI polymorphism and the risk of PD. Our results were analogous only with American/Hungarian Caucasian race.

Effects of Work-Related Stress on Work Ability Index among Iranian Workers

BACKGROUND: Work Ability Index (WAI) is a well-known and valid self-report tool that has been widely used in various studies to identify and avoid early retirement and work-related disability. Nevertheless, very few studies have been carried out to evaluate work ability in Iran. We aimed to investigate the WAI and the effect of work-related stress on it among Iranian workers. METHODS: A cross-sectional, descriptive and analytic study was carried out among 449 workers from five working sectors in three big cities of Iran. Work ability and work-related stress were measured using the Persian version of WAI and the Persian version of Health and Safety Executive Stress Indicator Tool. RESULTS: More than a third of the workers surveyed (34.70%) did not have an appropriate level of work ability (WAI < 37). There was a significant correlation between subscales of work-related stress and the mean score of WAI. Furthermore, the variables of body mass index, sleep quality, exercise activity, job tenure, and three subscales of work-related stress including demands, supervisor support, and role were significant predictors of WAI. CONCLUSION: According to the results of this study, the interventional programs must be focused on improving supervisors support, eliminating ambiguity and conflicts in the role of workers in their job and organization, reducing job demands, improving sleep quality, and increasing exercise activity.

Quality of Life among Iranian Infertile Women in Postmenopausal Period: A Cross-sectional Study

OBJECTIVES: Infertility has a significant impact on a women's quality of life (QOL). Infertile women face with physical and mental challenges during their postmenopausal period. Therefore, the present study aimed to evaluate the QOL among Iranian infertile women in the postmenopausal period using a valid and reliable instrument. METHODS: In this cross-sectional study both snowball and social networking methods were used for sampling. Two demographic and QOL questionnaire were used for data collection. The QOL questionnaire includes 41 items which measure the QOL in five dimensions: socioeconomic, mental health, religiousness, physical health and future imagining. Data analyzed was carried out in IBM SPSS ver. 20.0 using descriptive statistic, χ2 test, and Fisher test. A P value of 0.01 or less was considered significant. RESULTS: Overall 211 eligible participants were studied. Some participants obtained full score on socioeconomic, religiousness, physical health and future imagining dimensions of QOL but none on the mental health dimension of the QOL. Only, 6.6% of study participants have a good QOL. There was a significant relationship between age and financial provider whit status of QOL. CONCLUSION: Most Iranian infertile women in the postmenopausal period have poor or moderate QOL. Therefore, improving the QOL among these women should be considered.

Association Between Serum Calcium and Metabolic Syndrome Indicators among Women in Mazandaran, Northern Province of Iran

Introduction: Metabolic syndrome (MetS) is defined by indicators of hypertension, abdominal obesity, abnormal lipid profile, and hyperglycaemia. Few studies have investigated the association between serum calcium and MetS. Thus, this study examined prospectively the association between serum calcium in Iranian women with onset of MetS, and key components of MetS. Methods: A total of 460 subjects were recruited, comprising 232 with MetS and 228 as a control group. Waist circumference (WC) and blood pressure (BP) were measured and fasting blood samples were obtained for determination of glucose, insulin, total triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and serum calcium. Results: Compared to the control group, women with MetS had significantly higher WC, BP, TG, glucose, and LDL-C levels but lower HDL-C levels with 97.1±8.4 cm, 123.2±16 mmHg, 219.9±88.7 mg/ dl, 119.208.8 mg/di, 121.3±201 mg/dl, and 38.8±4.9 mg/dl, respectively. Serum concentrations of calcium were significantly higher in women with MetS (9.9±0.3 mg/dl) compared to the control group (9.1±0.7 mg/dl). Serum concentrations of calcium and phosphorus are predictors of MetS. Serum calcium level had a positive association with the risk of having high levels of glucose, TG, BP and WC. Conclusion: Serum calcium level showed a positive association with the risk of having high levels of parameters associated with MetS in the Iranian women studied. More studies on MetS are suggested to include measuring serum calcium as well to verify the present findings.

Association Between Serum Calcium and Metabolic Syndrome Indicators among Women in Mazandaran, Northern Province of Iran

Introduction: Metabolic syndrome (MetS) is defined by indicators of hypertension, abdominal obesity, abnormal lipid profile, and hyperglycaemia. Few studies have investigated the association between serum calcium and MetS. Thus, this study examined prospectively the association between serum calcium in Iranian women with onset of MetS, and key components of MetS. Methods: A total of 460 subjects were recruited, comprising 232 with MetS and 228 as a control group. Waist circumference (WC) and blood pressure (BP) were measured and fasting blood samples were obtained for determination of glucose, insulin, total triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and serum calcium. Results: Compared to the control group, women with MetS had significantly higher WC, BP, TG, glucose, and LDL-C levels but lower HDL-C levels with 97.1±8.4 cm, 123.2±16 mmHg, 219.9±88.7 mg/ dl, 119.208.8 mg/di, 121.3±201 mg/dl, and 38.8±4.9 mg/dl, respectively. Serum concentrations of calcium were significantly higher in women with MetS (9.9±0.3 mg/dl) compared to the control group (9.1±0.7 mg/dl). Serum concentrations of calcium and phosphorus are predictors of MetS. Serum calcium level had a positive association with the risk of having high levels of glucose, TG, BP and WC. Conclusion: Serum calcium level showed a positive association with the risk of having high levels of parameters associated with MetS in the Iranian women studied. More studies on MetS are suggested to include measuring serum calcium as well to verify the present findings.